Marinos Kallikourdis studied Natural Sciences at Trinity College, Cambridge, where he also received a PhD in the MRC Laboratory of Molecular Biology, on how regulatory T lymphocytes are necessary for maternal-fetal tolerance. Moving to Milan, he became a Group Leader at the Humanitas Research Hospital and Assistant Professor at Humanitas University. His group studies the role of adaptive immunity in Cardiovascular Disease, demonstrating in recent years how Heart Failure features a wide involvement of cardiac immune responses, how T cell blockade has therapeutic effects in different forms of heart disease, as well as how cardiac symptoms of Long COVID may be autoimmune-mediated.